Dermatopharmacokinetics of betamethasone 17-valerate: Influence of formulation viscosity and skin surface cleaning procedure

Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability.

BACKGROUND The bioavailability of most topically delivered drugs is difficult to quantify, but is generally believed to be very low. With the exception of the vasoconstrictor assay for corticosteroids, no methodology to quantify the rate and extent of drug delivery to the skin has been validated. Recent research has examined the dermatopharmacokinetic (DPK) technique, which is based on stratum ...

Betamethasone 17-valerate: a new alcoholic formulation for psoriasis of the scalp.

Betamethasone 17-valerate by aerosol in childhood asthma

Frears, J. F., Wilson, L. C., and Friedman, M. (1973). Archives of Disease in Childhood, 48, 856. Betamethasone 17-valerate by aerosol in childhood asthma. A double-blind cross-over trial of betamethasone 17-valerate (B17V) administered by aerosol was carried out by alternating two placebo periods with two treated periods at monthly intervals in 20 children with severe asthma. During the trial,...

Comparison of betamethasone 17-valerate ointment with fluocortolone and fluocortolone caproate ointment.

Topical corticosteroids have revolutionized the therapy of many dermatoses. The value to the dermatologist of commercially available preparations reflects many factors, including the cost, potency, therapeutic efficiency, and cosmetic acceptability of the medicaments. Furthermore, since the pharmacology of most corticosteroids is similar, and the newer fluorinated compounds are of high potency,...

Kinetics of Thermal Degradation of Betamethasone Valerate and Betamethasone Dipropionate in Different Media

The effect of pH, media, phosphate concentration and ionic strength on the kinetics of thermal degradation of betamethasone valerate and betamethasone dipropionate has been investigated. A validated HPLC method has been used to determine the parent compounds and their major thermal degradation products identified in the reaction. Betamethasone-17-valerate gave rise to two major products, namely...